Respiratory Disease doesn't play favorites. It affects men, women, children, smokers, non-smokers and individuals who have never smoked. If lung disease is taking your breath, you do not have to deal with it alone. Cigarette smoking is either a cause or an exacerbator (the reason lung disease is getting worse) of every respiratory disease on this list. It is the leading cause of preventable illness and death and produces 443,000 deaths a year, around 49,000 of which are caused by secondhand smoke.